Porphyrins, Quantitative, Random Urine

Number
120980

CPT
84120

Related Information

Aminolevulinic Acid, Delta, 24-Hour Urine
Aminolevulinic Acid, Delta, Random Urine
Porphyrins, Quantitative, 24-Hour Urine
Urine Testing: Preservative Quick Reference Chart

Synonyms
Coproporphyrin ; Uroporphyrin

Test Includes
Coproporphyrins I and III; uroporphyrins; hepatocarboxylporphyrins;
hexacarboxylporphyrins; pentacarboxylporphyrins

Specimen
Urine (random); protected from light

Volume
25 mL

Minimum Volume
5 mL

Container
Amber plastic urine container; no preservative or 5 g/L sodium carbonate (Na2CO3) is
acceptable. Do not use acid preservative.

Collection
Use amber plastic urine cup and amber top; order LabCorp No 20656. (If amber cups are unavailable, cover plastic container completely, top and bottom, with aluminum foil. Identify
specimen with patient name directly on the container and on the outside of the aluminum foil. Secure with tape.)

Storage Instructions
Refrigerate and protect from light.

Causes for Rejection
Stored specimen not refrigerated; specimen exposed to light; acid preservative; pH <3

Reference Interval

Coproporphyrin I: 0-15 µg/L
Coproporphyrin III: 0-49 µg/L
Heptacarboxylporphyrins: 0-2 µg/L
Hexacarboxylporphyrins: 0-1 µg/L
Pentacarboxylporphyrins: 0-2 µg/L
Uroporphyrins: 0-20 µg/L

Use
For initial evaluation of porphyrias. Use quantitative 24-hour porphyrins to follow up random urine abnormal results. See Porphyrins, Quantitative, 24-Hour Urine [003194] .

Limitations
See Porphyrins, Quantitative, 24-Hour Urine [003194] .

Methodology
High-pressure liquid chromatography (HPLC) with fluorometric detection